Notorious Fungus Blamed for ‘Mummy’s Curse’ Is Now a Promising Cancer Treatment

In the 1920s, the excavation group opened the grave of King Tutankham, a number of employees resulted in a timely death. Five decades died after entering 10 out of 12 scientists tomb Casimir King of Poland in the 15th century Casimir IV. In both cases, researchers suggested that mushroom spores could play one role In mysterious deaths, especially identify mushroom Aspergillus Flavus In the Polish burial.

A. Flavus Now it is a return turn, but not like a killer of reassured from the ancient tombs, but as a surprisingly effective cancer-battle combination. With the replacement of a newly defined molecule found in fungi, researchers created a combination effectively against leukemia cells such as the FDA-approved medications.

Molecules in the center of this cancer, known as ribosomally synthesis and post-translating peptides or RippsCollected by ribosome (pilgrims) and later are a variety of natural molecules that are changed by enzymes. They are conducting many different biological activities, some are already known for cancer Properties.

To date, researchers have identified a handful of rippers in fungi, which is much less than the thousands of bacteria. Part of the problem is that scientists fully understand how the fungi creates rippers.

“Synthesis of these compounds are complex,” said a posthandoral worker at Chemical and Biomolecular Engineering University of Pennsylvania, a university statement. “But this is what gives them this remarkable bioactivity.”

Genetic analysis suggested that a concrete A. Flavus Protein can be a source of mushroom rippers. Of course, when Nie and his colleagues, Adtein, the chemical markers of the RIPPs showed the crimes, but were extinguished. Using this approach, the team discovered four different A. Flavus Rippers with previously undocumented structures of the rings previously eliminated. After the researchers cleared these rippers, two of the four unique molecules, which they call the Asperigimycins, performed well to human leukemia cells without changing more.

When mixed with a lipid (a fat molecule), a separate ripps Both servaabine and Daunorubic, a long-established FDA-approved Lokemia and Daunorubic. Researchers returned to put out the genes to explore the development of the lipid. In this way, they have set a gene related to the process that allows cancer cells to grow enough asperiques.

“This gene acts as a gateway,” Nie is the first author of the work published on Monday Nature Chemistry Biology. “It simply does not help the asperiques to enter the cells, but other ‘cyclic peptides’ to do the same.” Tsurge peptides are other chemicals that have known drugs. “It gives another tool for drug development, to know how the lipids can affect the transportation of chemicals into cells,” Nie said.

Researchers also discovered that there is a good news to be a good news for the treatment of suspects and consists of uncontrolled cell distribution of cancer. In addition, the compounds did not affect breasts, liver or lung cancer cells, as well as a number of bacteria and fungi. Although this sounds like something negative, the potential target effect of Asperigimycins was an important character for future drugs. Forward progress, researchers aim to test asserpers in animal tests.

The latest research is investigating a promising new cancer therapy, but this will lead to fungal medicine for future research.

“Nature gave this incredible pharmacy,” he said. “Opening the secrets is for us.”