How the Binding of Two Brain Molecules Creates Memories That Last a Lifetime

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When TODD ​​SACKOR He was about 3 years old, his 4-year-old sister died of leukemia. “A blank bedroom next to the mine is a swing of two seat instead.” “It was a missing person – I had no memory.” This memory was weak, but sustainable, was established in the lower den. A young fake sister asked him to read a book from his sister and brushed him: “Go ask the mother.” The saccase wrapped the stairs to the kitchen.

It is noteworthy that more than 60 years, the feast remembers this fleeing childhood moment. The astonishing nature of memory is that every remembrance is a physical trace that is attached to brain tissue by molecular machines of neurons. The essence of an aged moment is coded and remains one of the unreasonable questions in the issues of neurology taken later.

The saccase was a neuroscientificist behind the answer. New York State University studies molecules that are low in the city of Brooklyn, to protect memorable relations. It was always the question that was attracted to originally expressed in 1984 Popular biologist Francis Crick: For years, even decades, even decades, even decades, for decades, weeks or for decades or months or for decades?

In 2024, we have been working with a team for a long time André fentonA neuroscientificist at the University of New York, the sheet, offered a potential explanation on a paper published Science advances. Researchers discovered that a continuous connection between the two proteins It is associated with the strengthening of the Sidaps with the relationship between the synopsons. Synaptic reinforcement is thought to be the basis for the formation of memory. As these proteins get worse, the new ones protect the integrity of the bond and therefore are in a molecular exchange in a molecular exchange that maintains the integrity of memory.

Francis Crick in 1984 described a biological client: In recent years, memories when most molecules worsen the day or weeks. “So what is being kept in the brain to be immune to the brain in the brain?” Wrote in the wild.

Photo: National Library of Medicine / Source of Science

Researchers presented “a very convincing case for interaction between the two molecules” for memory memory ” Karl Peter GieseA neurobiologist at London Royal College without work. The findings offer a compelling response to Crick by contacting the Dilemma inappropriate to explain how the ephemeral molecules protect the memories of how a lifetime is protected.

Molecular memory

Early in his career, the fetor, a discovery that would form the rest of his life. After reading the Molecular Memory Pioneer in Columbia University, James Schwartz opened his laboratory in Suny Downstate to look for a molecule that could explain how long it lasts.

The molecule he was looking for would be in the nail. In 1949, Psychologist Donald Hebb strengthened relations between neurons, which repeatedly activated neurons, or neuroobiologist Carla Shatz burned together, together, wires together. “For decades, many studies have been stronger and proposed to further increase the relationship between the neurons, and how many memories last.

In the early 1990s, a meal of a meal of a mouse in a lab, a small area of ​​a rat hipkampus, such as the memories of the events and locations, related to the memories of the memory coding and storage associated with neural roads, such as the memory coding and storage. Then he looked for any molecular change that happened. When he repeated the experience, he saw the high levels of a certain protein within the Sidaps. “On the fourth time, I was like that,” he said.