Poop Transplants Not All They’re Cracked Up to Be

There is fecal transplant appeared like a potential treatment for extensive conditionsIncluding irritated intestinal syndrome, diabetes and even depression. This so-called poop transplant has taken a lot of attention, but new studies throw a little wet blanket over the experience.

The procedure involves accepting germs from a healthy person’s poop and transfers them to a patient’s colon. This should restore the balance for intestinal microbioms, but according to a study published in June 6 SqueakTransplant germs can colonize the wrong parts of the digestive system. This can last a long time Untreated health resultsResearchers warn.

“I think we should not be asked for a little awakening call to the site so that we should not be there to not be there to put great guts to different parts of the intestine” gossip Chicago University is a postdortal researcher Orlando “Landon” Deleon device, “Landon” Deleon.

Deleon led the group of researchers through a group of experiments in mice to determine how the mice influence the different parts of the fecal transplant. The mice were divided into three groups. One took the secondary part of Jejunum (the middle of the small intestine), the second germs (a bag connected to the colon of the small intestine) and the third was a standard fecal transplant from the colon.

Each of the digestive system is an unparalleled microbiot. Researchers wanted to see the mice will stick to the appropriate niches once. In fact, each of the transplant, three months after the procedure, the “discrepancy”, which lasted until three months, saw the regional intestinal intestinal tract successfully.

In these intestinal regions, the potential to influence the patient’s health and behavior, germs that colonize the intestinal parts that cause metabolic changes in these intestinal areas. Researchers observed the change in the mice in eating, operating and energy costs after the transplant. They also documented changes in gene activity related to the immune function, which in turn caused changes in the liver metabolism. The most surprisingly, this was the method of gene and protein in the geni and extended intestinal region of foreign germs, the method of making an inappropriate intestinal region.

“This is like tender to help them to fit the engineering or environment,” Deleon said.

To determine if these discrepancies may occur in real transplant patients, colleagues and colleagues used additional tests using human tissue samples. The results showed that the transplanted intestinal bacteria can colonize the parts of the digestive system that does not naturally belong.

“If we are preparing a good therapeutic, we need to be aware of the importance of complying with the environment in accordance with the regional microbiot and we must provide better health benefits,” Deleon said. For example, the findings can be safer to use microbes from all parts of the digestive system, according to researchers.

Food and Drug Administration (FDA) only Recommend fecal transplantation for Treatment of recurring infections Clostridium difficileor C. different. This can cause bacteria, gastrointestinal symptoms, which can lead to most patient patients treated with antibiotics. There is fecal transplant produce To be highly enabled to treat this infection, and these results encouraged researchers to investigate other applications for this procedure.

A new research wave shows that the feces can treat the conditions that go beyond the intestine. Indeed, research found that this procedure could benefit the patients neurodevelopmental and Psychiatric disorders, Very sclerosis2 Type diabetes and more.

Deleon’s results offer to better understand the risks of fecal transplant, which can be used for illnesses other than the C. difference in doctors. He plans to investigate how various germs affect each part of the intestine and the way of being restored to the original state of modified regions.

This study shows that when it comes to intestinal germs, the place is really important. To get the right mistakes in the right place, can open the full potential of fecal transportation.