Scientists Discover the Key to Axolotls’ Ability to Regenerate Limbs

There are still gaps in current research: cyp26b1 How is the gradient adjusted, how retinoic acid closes Shox Determines the formation of special structures such as genes and low-flow factors, humerus or radius bones.

From the recovery of healing

Monaghan explains that there is no “magic gene” for the restoration of Axolootls, but does not share the same fundamental genes as human. “The main difference is accessory those genes. Although people activate the genes that make an injury injury in humans, there are in salamanders cell de -i: Cells return to a state like an embryo that can meet signals such as retinoic acid. The ability to return to the ‘development situation’ is the basis of their recovery, “the researcher informs.

So if people have the same genes, why can’t we restore? “The difference is that Salamander can re-collect this [developmental] program after injury. “People – only before the initial growth before childbirth, they cannot enter this development.” Mondhan says.

James Monaghan.Photo: University of Alyssa Stone / Northeastern

Monaghan says that the theoretically did not need to restore DNA, but to change the body and place to intervene in the body and location of the Van. For example, a cell is re-activated in the regenerative environment, not a cell with a pink side and thumb, not in the elbow, but not in the regenerative environment. “This concept can be applied in stem cell treatment.

After annual work, it has been a source of deep satisfaction for Monaghan, which has been read in retinoic acid since 1981. A patch placed in a scientist is a future imagination, can recreate development programs in human cells that imitate the regenerative mechanism of Salamander. Although it is not immediately, it believes that the sales of germination is the restoration of the science.

It reflects how Axolotl’s second scientific life is. “It was a dominant model a hundred years ago, it can be demolished in ten years ago and can learn any genes and cells and cell and cell as a gene regulation and cell analysis.

This story originated first String in Spanish and has been translated from Spanish.