This Novel Substance Might One Day Block Severe Inflammatory Reactions Like IBS and Asthma

Mast cells It is part of our immune system, protects our body from viruses, bacteria and even harmful substances released by snake and insect bites. While warning the fact that such invaders warn, mast cells can create mucus, trigger and itching, stomach, stomach and bowels. These symptoms cause allergic reactions, including extreme mast cells, including the destruction of the body’s invaders, but also vital hazards and treatment conditions.

As a learn The magazine, published magazine, and target therapy, researchers, researchers, prepared a combination of mast cells, especially from blocking of vital dangerous reactions. These include irritated intestinal syndrome (IBR), asthma, chronic itching and migraines. Traditionally considered false allergic reactions, these terms are classified as the researchers, these conditions are more classified as a type of allergies. Reduces complex symptoms, and eventually reduces the risk of death.

“Thus, we see this as an extremely promising substance,” Christa Müller, who investigated the medicinal chemistry of membrane proteins at Bonn University, said at a university statement.

Unlike some allergic reactions called antibodies with the participation of antibodies, the mast cells occur in this difficult situation with the participation of invaders in this difficult situation with direct activation. It triggers the reactions of a certain nature that is difficult to treat and stay so far, “he said.

15 years ago, Müller and colleagues identified a receptor called MURPRX2 in the mast cells mast cells certain molecules Add. “To prevent this reaction, the transition would somehow be closed,” he said. “The question is: how?”

To solve this, the team tested promising compounds from the 40,000 40,000 collections collected by the Müller branch. “We used cells when MRGPRX2 are activated, so we used the signal of the light, which effectively block the receptor’s activation,” he said. In this way, the team found a molecule that can effectively connect and block it to the receptor.

They still used a molecule to develop a substance that works very low and proved effectiveness in blocking MRGPRX2 receptors in human mast cells in the laboratory mice. Only the molecule blocked the risk of side effects, claimed that the molecule had blocked the planned receptor.

Al Hamwi, Müller and colleagues, when the effectiveness and duration of the substance improved since then, more animals and as a result will have to happen before trading human trials as a medicine. Nevertheless, some inflammatory conditions are conducting potential life-saving effects for patients with an anaphylactic shock.